Janumet is a combined drug that includes two active ingredients, namely metformin & sitagliptin.
To understand the principle of action of the med, you should first find the answer to the question: what is metformin?
This is a chemically synthetized substance, which lowers basal & post-meal plasma glucose. Sitagliptin is another antidiabetic agent, which belongs to DPP-4 inhibitors and acts by slowing inactivation of incretins, hormones that lead to a decrease in blood sugar rates. Combination of these two agents makes the action of the med more powerful. It helps control blood glucose rates during the day, in particular, after meals.
Janumet generic is significantly cheaper than the genuine version. This is due to the fact, that its manufacturers bear fewer costs for the production of the drug, because they use already the developed formula. There are no differences between a branded and generic version in terms of effectiveness & quality.
Is it For Me?
The medical remedy is taken as an addition to the proper nutrition and exercise regimen to enhance glycemic control in persons suffering from type II diabetes who haven’t achieved adequate control when using monotherapy either with metformin or sitagliptin, or after unsuccessful combined treatment with two meds. It may also be used by patients who simply take two meds (as separate tabs) simultaneously.
There are some counter indications to Janumet use:
individual sensitivity of the body to any drug components;
acute conditions that may affect the work of kidneys, for instance, severe dehydration, serious infections and shock state;
kidney dysfunctions of moderate or serious severity;
severe liver dysfunctions;
acute intoxication after consumption of alcoholic drinks;
period of lactation in females;
type 1 diabetes;
metabolic acidosis of acute or chronic nature, including diabetic ketoacidosis;
undergoing radiological diagnostic studies (intravascular injections of iodine-containing contrast substances);
acute or chronic illnesses that are able to lead to tissue hypoxia, for example, cardiac / respiratory failure, recent myocardial infarction.
The med may be consumed during pregnancy if the potential risk of its use is less than positive effect of the therapy. But one should bear in mind that adequate and large-scaled studies on this matter haven’t been performed yet.
How do I choose the right dosage?
These diabetes pills come in the following dosage:50/500. What does it mean? It means that one Janumet pill contains 50mg of sitagliptin and 500mg of metformin hydrochloride.
The correct dosage should be chosen individually but it shouldn’t exceed maximal daily dose of sitagliptin, which is 100mg, and metformin, which is 2000mg. The exact dosage is prescribed by a doctor considering such factors as effectiveness of previous therapy, severity of the disease, and individual tolerance.
How do I take Janumet?
It is advised to take the drug with meals to minimize the risk of stomach upsetting. The tabs should be swallowed whole. Don’t cut them before consumption and don’t chew them. Janumet is usually taken 2 times a day. It is crucial not to miss the drug intake when treating diabetes.
What are the mechanisms behind Janumet?
The medical remedy targets three main factors to decrease blood glucose levels:
It increases the ability of the pancreas to produce more insulin;
It helps the human body to use self-synthetized insulin more efficiently.
It leads to a decrease in excess sugar produced by liver.
What is Janumet uptake time?
Correct treatment with the tablet provides the necessary effect during a 24-hour period. Therefore, the time of Janumet’s action start isn’t important in this case. However, it is known that active substances are absorbed quickly after administration.
How efficient is Janumet?
Janumet is a FDA-approved drug. Its effectiveness has been tested in multiple research, in particular, in studies by St Onge EL et al. (2012), Reynolds JK et al. (2008), Onge ELS et al. (2012).
The substances that are contained in Janumet have also been studied separately. All studies showed high safety profile and great effectiveness of the pharmaceutical combination Janumet 50/500.
Does Janumet have any side effects?
You know, all drugs may potentially cause undesirable side effects. Janumet side effects include:
abdominal pain, nausea & vomiting (these side effects are quite typical for anti-diabetic meds; to decrease the risk of their occurrence, take the pills with food);
lack / loss of energy;
stuffy / runny nose;
anxiety disorders, dispiritedness;
clouding of consciousness etc.
Metformin, one of the key ingredients of the medicament, may lead to very rare but quite dangerous side effect. It is named lactic acidosis which implies formation of lactic acid in the bloodstream. The condition requires hospital treatment as it may lead to lethal outcome. A patient should call his / her doctor urgently if he / she feels symptoms of lactic acidosis: severe tiredness, feeling of cold in upper & lower extremities, non-usual muscle aches, bad breathing, heartbeat disruption, lightheadedness, severe stomach disorders.
Any essential tips on Janumet use?
The action of the med may be decreased by diuretics, corticosteroids, estrogens, sympathomimetics, and some other medicaments. Tell your healthcare professional about all medicaments you take to prevent undesirable interactions.
Under normal conditions, during Janumet monotherapy, hypoglycemia doesn’t develop, but its development is possible in fasting condition, after considerable physical exertion without subsequent compensation of consumed calories and while taking other hypoglycemic diabetes medications. So do not skip meals during treatment.
Alcohol consumption during Janumet-based therapy increases the possibility of developing hypoglycemia and lactic acidosis. Therefore, it is not recommended to take ethanol when using the medicament.
Do not forget about proper diet, which is suitable for diabetics, and exercise regimen.
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