Before you buy Singulair online
What It Does?
Singulair is indicated in asthma as an add-on therapy in patients with mild to moderate persistent asthma who are inadequately controlled on inhaled corticosteroids and in whom as-needed short-acting beta-agonists provide inadequate clinical control of asthma. Singulair 4 mg granules used in children aged 6 months to 5 years. Singulair 4 mg chewable are tablets used in children aged 2 to 5 years.
In those asthmatic patients in whom Singulair is indicated for asthma, Singulair 10 mg also provides symptomatic relief of seasonal allergic rhinitis.
Canadian Singulair is also indicated in the prophylaxis of asthma from 2 years of age where exercise-induced bronchoconstriction is the dominant component.
Singulair may also be an alternative to low-dose inhaled corticosteroids for patients with mild persistent asthma. This applies 2-14 year old patients who have not recently had serious asthma attacks that required oral corticosteroid use and who have shown that they are not capable of using inhaled corticosteroids.
How It Works?
Asthma is a disease affecting the lower airways and allow the passage of air to and from the lungs more difficult. When you have asthma seizure, the muscles of the bronchi constrict. The airways become narrow and it becomes hard to breathe. Bronchial mucosa also becomes inflamed.
Leukotrienes are substances that the body forms itself and that mediate inflammatory reactions, including those in the airways. These infections can lead to getting a swollen irritated mucous membrane of the bronchi and muscle spasm of the bronchi. The active ingredient in the medication, montelukast, blocking some of these reactions. This reduces the risk that they get asthma symptoms.
How It Is Taken?
One should take chewable tablets on an empty stomach, either one hour before meals or two hours after a meal. If you have food in your stomach taken medication is not absorbed in the body as well, and the medication can get worse effect. The tablets in the strength of 10 milligrams and granules can however be taken with or without food. The granules can be taken directly by the mouth or with such a spoonful of applesauce or ice cream. One should not loose granules in the water but you can drink the liquid directly after you have taken the granules. Once you have opened the sachet of granules you should take it in the fourth. You should never store food mixed with granules for use at a later time.
Is It For Me?
Patients with hypersensitivity to the active substance or to any of the excipients should not take Singulair.
Any Drug Interactions or Incompatibilities?
Montelukast may be administered with other therapies routinely used in the prophylaxis and chronic treatment of asthma. In interaction studies, the recommended clinical dose of montelukast did not have clinically important effects on the pharmacokinetics of the following medicinal products: theophylline, prednisone, prednisolone, oral contraceptives, terfenadine, digoxin and warfarin.
AUC of montelukast was decreased approximately 40% in subjects with co-administration of phenobarbital. Since montelukast is metabolised by CYP 3A4, 2C8 and 2C9, caution should be exercised, particularly in children, when montelukast is coadministered with inducers of CYP 3A4, 2C8 and 2C9, such as phenytoin, phenobarbital and rifampicin.
In vitro studies have shown that montelukast is a potent inhibitor of CYP 2C8. Data from a clinical drug-drug interaction study involving montelukast and rosiglitazone (a probe substrate representative of medicinal products primarily metabolized by CYP 2C8) demonstrated that montelukast does not inhibit CYP 2C8 in vivo. Montelukast is not expected to significantly affect the metabolism of drugs metabolized by this enzyme (eg, paclitaxel, rosiglitazone, and repaglinide).
What Side Effects Should I Brace Myself For?
A few people may experience side effects from the medication, such as upset stomach, headaches, skin problems, fever or upper respiratory infection.
Any Important Tips?
Remember that shopping for your pills responsibly is investing in your health. Do not buy from random retailers.
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