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Active Ingredient: Estradiol

Estrace is an estrogen-containing drug intended for various symptoms of female menopause.


Estrace 1 mg
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90 pills
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per item
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Before you buy Estrace online

What is Estrace?

Estrace is an estrogen-containing drug intended for females. There are two types of the medication: tablets and cream. They’re used for treating signs of menopause, such as vaginal burning and dryness. In addition, Estrace tabs may be prescribed for other reasons, such as estrogen replacement therapy in female persons suffering from ovarian failure.

The medication treats unpleasant sensations on the vulva and inside the vagina. Lubricants, which are commonly used by women, can reduce the symptoms but they cannot fight against the underlying cause, in contrast to Estrace.

Is it For Me?

Estrace tabs with systemic action are usually prescribed in cases of severe menopausal symptoms and other diseases associated with deficiency of natural estrogen in the body.

There are some counter indications for using the medication.

Here is the list of them:

  • hypersensitivity to the main or additional components of the drug;
  • breast cancer or suspected cancer;
  • estrogen-dependent tumors;
  • active thrombophlebitis or thromboembolism;
  • impaired renal and hepatic function;
  • sickle-cell anemia;
  • prolonged immobilization (recumbent patients);
  • syndromes of Dubin-Johnson and Rotor;
  • vaginal bleeding of unclear etiology;
  • pregnancy and lactation.

How do I choose the right dosage?

For pills: Estrace tablets are usually used for 3-6 months. The minimal possible dosage for controlling menopause symptoms should be chosen. Typically, the treatment is started with 1-2 g per day. The doctor should adjust the dosage according to medical tests data and the woman’s feedback. Estrogen therapy is cyclic (for instance, 3-week administration and 1-week break). If the medicament is used for treating other conditions, dosage and therapy regimen are different.

How do I take Estrace?

Use the medication as prescribed by your healthcare professional. It is recommended to take the tablet (or use the cream) at approximately the same moment of the day. If you take tablets, wash them down with water.

What to do if you have missed the administration?

Take the pill/use the cream as soon as you understand that the dose is missed. If you see that the time for the next administering will come soon, skip the missed Estrace dosage. Don’t administer a double dose.

What are the mechanisms behind Estrace?

Estrogens are responsible for the development, preservation of the female reproductive system and the formation of female secondary sexual characteristics. The main source of these hormones is the egg follicle. After menopause, most of the estrogen in the body is obtained by transforming the androstenedione, produced by the adrenal glands, into estrone (less potent type of estrogens).

Estrogens regulate the secretion of gonadotropin, luteinizing hormone & follicle-stimulating hormone, through the mechanism of negative feedback. Estrace reduces the elevated levels of these hormones in postmenopausal female persons. The complex effect of the drug leads to the normalization of hormone levels and the elimination of negative symptoms of menopause.

What is Estrace uptake time?

Estrace tabs are quickly absorbed in the body. However, their action becomes visible several days after starting the treatment. The tabs’ effect may be achieved more quickly but the cream of Estrace provides softer and safer action.

How efficient is Estrace?

Estrace has great effectiveness. Most menopenausal women who use it have noted a significant improvement in symptoms.

Estrogen treatment provides the following beneficial effects:

  • vaginal pH normalizing;
  • tissue thickening (atrophy reduction);
  • increasing of lubrication.

Does Estrace have any side effects?

The adverse effects of Estrace pills or cream may be mild and short-term, or more severe. Some crucial adverse effects can signal of the necessity to stop the treatment immediately and urgently seek medical help.

Find side effects of the medication below.

Estrace side effects:

  • allergic reaction symptoms, such as hives, rash, redness of the skin, skin blistering, swelling, etc.;
  • upset stomach, bloating;
  • increased or decreased libido, dizziness;
  • headache, nausea;
  • hypersensitivity of the breast;
  • problems with the gallbladder;
  • chest pain;
  • worsening of vaginal symptoms, and others.

If you experience such rare but serious adverse events as swelling of the hands or feet, bumps in the chest, unusual vaginal bleeding, ophthalmic changes, unusual vaginal discharge, chest pain, mood changes (for instance, serious depression, memory loss), problems with breathing, sudden severe headaches, inform your doctor immediately.

Most women do not experience severe side effects. Women over 65 should use the remedy with care, as it can lead to more adverse events.

Any essential tips on Estrace use?

  1. If you suffer from diabetes mellitus (type 1 or type 2), you have to monitor your glucose rates more closely.
  2. Regularly undergo gynecological examinations & check the condition of the breast. Your prescriber should tell you how often you should do this.
  3. Limit the consumption of alcoholic beverages. It is desirable to minimize the consumption of grapefruit, since this fruit can enhance the effect of the medicine.

Store Estrace between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Estrace out of the reach of children and away from pets.


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