Allopurinol

Before you buy Allopurinol online

Allopurinol is used to treat gout condition with abnormally high uric acid levels in serum, especially in connection with gouty nephropathy or urate stones. It can be also appointed for secondary gout and secondary hyperuricemia brought on by diseases with excessive nucleoprotein catabolism (acute and chronic leukemia, polycythemia vera, myeloma, etc.).

Allopurinol can be used as prophylaxis against uric acid nephropathy during intensive treatment of neoplastic conditions with radiotherapy or antineoplastic preparations where fast tissue destruction may occur.

Allopurinol(Zyloprim) inhibits the body's uric acid synthesis by blocking the enzyme xanthine oxidase. Xanthine oxidase catalyzes the conversion of hypoxanthine to xanthine and xanthine to uric acid. Thus reducing the uric acid level in serum and the rate of urate excretion in urine decreases, which leads to the mobilization and dissolution of urate deposition in tissues. The formation of urate stones and gravel in the urine is thus prevented.

In mild cases adults should be given 100-200mg daily. In moderate cases, 300-600mg daily. In severe cases, doses up to 700-900mg daily is required. Up to 300mg Allopurinol Nordic Drugs can be given in a single dose. Doses greater than 300mg should be divided over the day.

Children 6-10 years: 100mg 3 times daily.

Children under 6 years: 50mg 3 times daily.

You should not use Allopurinol if you are allergic to the main medicinal ingredient or any other ingredients of this medicine (magnesium stearate, gelatine, sodium, microcrystalline cellulose, talc, corn starch, colloidal anhydrous silica).

The following combinations with Allopurinol may require dose adjustment: ampicillin, azathioprine, cyclosporine, cyclophosphamide, mercaptopurine, and theophylline.

Substances that increase the excretion of uric acid probenecid and high doses of salicylates, may increase excretion of Allopurinol's major metabolite, oxypurinol, which in turn can lead to reduced therapeutic effect of Allopurinol. This must be assessed case by case.

There have been rare reports of increased effect of warfarin and other coumarin anticoagulants when co-treatment with Allopurinol (Zyloprim). Patients being treated with coumarin anticoagulants should be closely monitored.

Rare: Aplastic anemia, agranulocytosis, leukopenia, leukocytosis, thrombocytopenia, kidney failure, granulomatous or maculopapular changes, itching, redness, scaling, Stevens-Johnson syndrome, toxic epidermal necrolysis, Lyell syndrome, erythema multiforme, furunculosis; general hypersensitivity syndrome including fever, angioneurotic edema, lymphadenopathy, vasculitis, arthralgia, eosinophilia; hepatobiliary disorders; hepatitis, including hepatic necrosis and granulomatous hepatitis.

Very rare: Seizures.

Uncommon: Nausea, vomiting, diarrhea; hepatic function disturbances

Common: rash occurs in approximately 4% of patients with normal renal function and in up to 15% of patients with renal impairment.

Allopurinol - contraindications, warnings and precautions

Hypersensitivity reactions to allopurinol may be manifest in many different ways, including maculopapular rash, hypersensitivity syndrome and SJS / TEN. These reactions are clinical diagnoses and their clinical manifestations constitutes the basis for decision making. If such reactions occur at any time during treatment, allopurinol immediately exposed. Restocking should not be done in patients with hypersensitivity syndrome and SJS / TEN. Corticosteroid therapy may be beneficial for relieving skin hypersensitivity.

Allopurinol should not be prescribed to patients treated with azathioprine or mercaptopurine unless the dosage of the latter is reduced to a quarter. As a xanthine oxidase inhibitor allopurinol prevents the metabolic inactivation of azathioprine and mercaptopurine, why serum concentrations of the latter with unchanged dosage can rise to toxic (potentially lethal) levels.

Very rare cases of aplastic anemia with fatal outcome have been reported during treatment with Allopurinol. Renal impairment may be a risk factor, and the dosage should be adjusted to this. If there are any signs or symptoms of blood injuries, the discontinuation of Allopurinol should be considered.

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