New Way of Coronavirus Transmission Has Been Revealed

Sunday 22nd of March 2020

A new way of contamination with the novel coronavirus has been recently revealed. Scientists from China have found that the Wuhan coronavirus can penetrate the human body not only via the ACE-2 receptor, but also via protein growth of the cluster of differentiation 147 (CD147 or basigin) molecule.

Earlier scientists believed that coronavirus could penetrate into the human cells with the help of combination of protein S and ACE2 enzyme. This leads to damage of tissues.

ACE2 is abbreviation of angiotensin converting enzyme 2, which belongs to exopeptidases. There are studies that the protein encoded by ACE2 is a functional receptor for the spike glycoprotein of the human coronavirus (NCBI, updated on 13-Mar-2020).

Microbiologists say that this enzyme is found in large quantities in the cardiac cells, kidney and genital cells, so the fight against the virus through this protein can adversely affect the condition of internal organs. (By the way, there have been statements that people recovered from coronavirus can develop infertility.)

However, on March 16, 2020, Chinese experts from Beijing Institute of Biotechnology and the Air Force Medical University (formerly known as the Fourth Military Medical University), based in Sian, came up with good news, they told media about new method of fighting against COVID, which implies influence on CD147 molecules.

The fact is that coronavirus can get into the organism through the protein outgrowth of basigin molecule.

These molecules are important when applying therapeutic measures against other viral diseases and malaria. Clinicians tried to treat the lung tissue with antibodies that oppress the activity of CD147 molecules, and made an attempt to infect them with a dangerous illness. It became pretty clear that antibodies effectively and mercilessly blocked the further spread of the viral disease in tissues of the lungs which are very vulnerable to the deadly virus.

The outcomes of new studies indicate that antimalarial drugs and agents for treating SARS may be useful in combating the coronavirus pandemic.

Scientists from the University of Queensland have confirmed new data. It should be noted that they used chloroquine (anti-malaria pills) and lopinavir plus ritonavir (HIV pills under the brand name Kaletra) for the treatment of COVID-2019. These funds showed high efficiency and led to a complete recovery of coronavirus sufferers.


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